In the 1600s, long before the invention of photography, a scientist named Girolamo Fumagalli was obsessed with the idea of reproducing images. He discovered that by killing a victim and removing the victim's eyeballs, it was possible to reproduce on paper the last image imprinted on that person's retinas. He named this technique 'thanatography'. Today, the same kind of gruesome ritual and abominable crime recurs within the walls of an international school of cinema.

In war-torn Japan, the Tokugawa Shogun, desperate to restore peace to his people, orders the assassination of the hostile warlords. A beautiful young woman is raised from birth with nine other orphans, to become an assassin. Her name is AZUMI, the ultimate assassin.